Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli Rosetta2 (DE3) cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G888W | inactive | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(beta,beta-dimethylacryl)shikonin | 64% inhibition at 0.01 mM; 64% inhibition at 0.01 mM | Homo sapiens | |
bergapten | 69% inhibition at 0.01 mM; 69% inhibition at 0.01 mM | Homo sapiens | |
deoxyshikonin | 67% inhibition at 0.01 mM; 67% inhibition at 0.01 mM | Homo sapiens | |
DMSO | at 2% (v/v) DMSO isoform ARTD10 loses more than half of its activity; at 2% (v/v) DMSO isoform ARTD7 loses its activity completely | Homo sapiens | |
EB-47 | i.e. 5'-deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine dihydrochloride; i.e. 5'-deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine dihydrochloride | Homo sapiens | |
embelin | 57% inhibition at 0.01 mM; 57% inhibition at 0.01 mM | Homo sapiens | |
gambogic acid | 75% inhibition at 0.01 mM; 75% inhibition at 0.01 mM | Homo sapiens | |
gossypol | 75% inhibition at 0.01 mM; 75% inhibition at 0.01 mM | Homo sapiens | |
menadione | 55% inhibition at 0.01 mM; 55% inhibition at 0.01 mM | Homo sapiens | |
myricetin | 78% inhibition at 0.01 mM; 78% inhibition at 0.01 mM | Homo sapiens | |
olaparib | i.e. 4-[(3-[(4-cyclopropylcarbonyl)piperazin-4-yl]carbonyl)-4-fluorophenyl]methyl(2H)phthalazin-1-one; i.e. 4-[(3-[(4-cyclopropylcarbonyl)piperazin-4-yl]carbonyl)-4-fluorophenyl]methyl(2H)phthalazin-1-one | Homo sapiens | |
phenantridinone | i.e. 6(5H)-phenantridinone; i.e. 6(5H)-phenantridinone | Homo sapiens | |
Plumbagin | 67% inhibition at 0.01 mM; 67% inhibition at 0.01 mM | Homo sapiens | |
TIQ-A | i.e. 4H-thieno[2,3-c]isoquinolin-5-one; i.e. 4H-thieno[2,3-c]isoquinolin-5-one | Homo sapiens | |
trimethylpsoralen | 61% inhibition at 0.01 mM; 61% inhibition at 0.01 mM | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
x * 25000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q460N3 | - |
- |
Homo sapiens | Q53GL7 | - |
- |
Purification (Comment) | Organism |
---|---|
HisTrap column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + (ADP-D-ribosyl)n-serine/arginine-rich protein-specific kinase 2 | - |
Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-serine/arginine-rich protein-specific kinase 2 + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 25000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ARTD10/PARP10 | isoform | Homo sapiens |
ARTD7/PARP15 | isoform | Homo sapiens |
mono-ADP-ribosyltransferase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
ARDT7 | Homo sapiens |
8 | - |
ARDT10 | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000232 | - |
isoform ARDT7, pH and temperature not specified in the publication | Homo sapiens | TIQ-A | |
0.000745 | - |
isoform ARDT10, pH and temperature not specified in the publication | Homo sapiens | phenantridinone | |
0.000925 | - |
isoform ARDT7, pH and temperature not specified in the publication | Homo sapiens | olaparib | |
0.00114 | - |
isoform ARDT7, pH and temperature not specified in the publication | Homo sapiens | phenantridinone | |
0.00118 | - |
isoform ARDT10, pH and temperature not specified in the publication | Homo sapiens | EB-47 | |
0.00204 | - |
isoform ARDT10, pH and temperature not specified in the publication | Homo sapiens | olaparib |